Decreased plasma soluble erythropoietin receptor in high-altitude excessive erythrocytosis and Chronic Mountain Sickness
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Decreased plasma soluble erythropoietin receptor in high-altitude excessive erythrocytosis and Chronic Mountain Sickness
Excessive erythrocytosis (EE) is the hallmark of chronic mountain sickness (CMS), a prevalent syndrome in high-altitude Andean populations. Although hypoxemia represents its underlying stimulus, why some individuals develop EE despite having altitude-normal blood erythropoietin (Epo) concentration is still unclear. A soluble form of the Epo receptor (sEpoR) has been identified in human blood an...
متن کاملNoninvasive Assessment of Excessive Erythrocytosis as a Screening Method for Chronic Mountain Sickness at High Altitude.
Vyas, Kaetan J., David Danz, Robert H. Gilman, Robert A. Wise, Fabiola León-Velarde, J. Jaime Miranda, and William Checkley. Noninvasive assessment of excessive erythrocytosis as a screening method for chronic mountain sickness at high altitude. High Alt Med Biol 16:162-168, 2015.--Globally, over 140 million people are at risk of developing chronic mountain sickness, a common maladaptation to l...
متن کاملTitle : Plasma soluble erythropoietin receptor is decreased during sleep in Andean 1 highlanders with Chronic Mountain Sickness
Corresponding Author: 14 Francisco C. Villafuerte 15 Laboratorio de Fisiología Comparada. 16 Departamento de Ciencias Biológicas y Fisiológicas. 17 Facultad de Ciencias y Filosofía. 18 Universidad Peruana Cayetano Heredia. 19 Av. Honorio Delgado 430. Lima 31. PERU 20 Tel/Fax: +51-1-3190000 Ext. 2421 21 E-mail: [email protected] 22 Articles in PresS. J Appl Physiol (April 28, 2016). ...
متن کاملHigh serum testosterone levels are associated with excessive erythrocytosis of chronic mountain sickness in men.
Chronic mountain sickness (CMS) is characterized by excessive erythrocytosis (EE) secondary to hypoventilation. Erythropoietin (Epo) and testosterone regulate erythrocyte production. Low thyroid hormone levels are also associated to hypoventilation. Hence, these hormones can play a role in etiopathogeny of EE. The purpose of this study was to elucidate the effect of sexual and thyroid hormones ...
متن کاملHigh Altitude Mountain Sickness
Its probable first account has been given by Plutarch in his comments on Alexander’s invasion of India: “Many then were the dangers— but the greatest harm came from severity of weathers”. Similarly, a Chinese record mentions of “Lesser Headache Mountains” and the “Greater Headache Mountains” where men’s bodies become feverish, they lose color and are attacked with headache, dizziness and vomiti...
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ژورنال
عنوان ژورنال: Journal of Applied Physiology
سال: 2014
ISSN: 8750-7587,1522-1601
DOI: 10.1152/japplphysiol.00619.2014